Defending the Indefensible?
by Margaret Williams 27th December 2011
Professor Simon Wessely once again attempts to defend what has already been shown to be indefensible, namely his own beliefs about the nature of ME/CFS, including his belief that graded exercise therapy (GET) has “an impeccable safety record” (Simon Wessely; Health in mind and body; The Journal of the Foundation for Science and Technology: 2011:20:7: 9 –11).
The article contains so many insupportable assertions that it cannot go unchallenged.
In his article, although he does not mention ME as such, Wessely refers to Chronic Fatigue Syndrome (CFS), but in countless articles published in medical journals, reports from official bodies such as the Joint Royal Colleges, in medical textbooks and in the media, as well as in the PACE Trial literature itself, the Wessely School insist that ME and CFS are synonymous.
In this latest article (the publishing of which is perhaps surprising, given his frequent assertions that he has relinquished his work on ME/CFS and that he no longer feels safe publishing about the disorder because of the death threats he has received, and that he now feels safer in Afghanistan), Wessely conforms to his track record of appearing to form his conclusions before he has generated the data to support his conclusions - (he often states his assumptions and beliefs as though they are established fact; for example, he has asserted that people with ME benefit from “adopting the sick role” and from “secondary gain”, and that what “precipitates” ME is not what “perpetuates” it, all of which are supposition not supported by data; a further illustration is to be seen in his study of Vitamin B status in just 12 CFS patients in which he found evidence of reduced functional vitamin B status but concluded: “clearly, many patients with CFS are currently taking vitamin B…with little evidence of benefit”, yet nowhere does he provide any evidence that “many” patients are taking supplements with little evidence of benefit and his final conclusion again fails to follow from his data: JRSM 1999:92:183-185).
Wessely’s
assertions in his current article are of particular interest
because they provide such clear illustration of his cognitive
biases, for example:
“CFS
illustrates the gap that lies between physical health/illness on
the one hand and mental health/illness on the other”: all
life-destroying diseases affect both physical and mental health,
not just ME/CFS.
“CFS is a
multi-factorial illness”:
Wessely does not know this, since the cause remains
unknown.
“To understand
why some people do not get better as the months and years go by,
one has to look at behavioural and psychological factors”:
this is nothing more than Wessely’s assumption; people do not
recover from multiple sclerosis or from motor neurone disease,
so it is telling that he makes an exception only in the case of
one particular classified neurological disorder (ME/CFS): why do
so, unless it is as a face-saving measure because for the last
25 years the Wessely School have rigidly and unscientifically
conflated psychiatric fatigue with ME/CFS?
“The illness is
then a complicated mixture of predisposition, precipitation, and
perpetuation”
| “A landmark trial on the management of CFS, known as the PACE Trial, was published recently in The Lancet….Two treatments, graded exercise and CBT, clearly made a difference, although they were certainly not ‘magic bullets’: not only were the interventions used in the PACE Trial very far from being magic bullets, the Chief Principal Investigator himself described them as being “only moderately effective”. |
| “For those who appreciate these things, the trial is a thing of beauty”: for those who appreciate these things, the PACE Trial -- which cost £5 million -- has been described as a travesty of science and a tragedy for patients; the conclusions were flawed; the primary outcome measures were dropped; ratings that would qualify a participant as sufficiently impaired to enter the trial were deemed by the Principal Investigators (PIs) to be “within the normal range” when recorded on completion of the trial; there were significant conflicts of interest in that all three PIs work for the insurance industry (whose managers insist that claimants undertake a course of CBT and GET -- called “rehabilitation” -- which, if people are too ill to do so or if they know from their own experience that it makes worse and therefore decline, payments are stopped on the basis that claimants do not to want to get better); the PIs intentionally studied a heterogeneous population and it was conceded only after publication of the results in The Lancet that the Investigators did not purport to be studying ME; there was a failure to control the trial; there was downgrading of what constituted serious adverse events; there were many changes to the entry criteria; data was not reported and objective outcome measures were dropped; methods of scoring were changed so as to produce minimally better results, and the results were blatantly misreported in The Lancet (see http://www.meactionuk.org.uk/COMPLAINT-to-Lancet-re-PACE.htm and see also http://www.investinme.org/Article425%20Hooper%20Further%20Concerns%20on%20PACE%20Trial%20article%20published%20in%20Lancet.htm). |
| “We now have two treatments that we can recommend with confidence to our patients. However, the story does not quite end there. Patient groups rejected the trial out of hand, and the internet was abuzz with abuse and allegations. The main reason for this depressing reaction was the stigma that attaches to disorders perceived (rightly or wrongly) to be psychiatric in origin”: the reason people with ME/CFS reject CBT and GET is because they do not work, but Wessely refuses to accept this, so he here provides an explanation already shown by his own research to be incorrect. |
He has previously written:
|
“CFS sufferers are also usually portrayed as hostile
to psychological explanation, mental illness, and psychiatry in
general….This study aims to investigate attitudes of CFS
patients to psychiatric illness (and) a comparison group of
patients with rheumatoid arthritis (RA) was chosen….We began
with the following hypotheses: CFS patients have more negative
attitudes to mental illness…(represented by the perceived stigma
of psychiatric illness)…(and) failure to identify emotional
states (alexithymia) contributes to denial of the role of
psychiatric disorders in the aetiology of CFS….Contrary to
our hypotheses and the media accounts of CFS, we found no
evidence that CFS patients are characterized by particularly
hostile attitudes to mental distress….Our study also failed to
demonstrate any overall differences in personality traits that
may underlie negative attitudes to mental illness or
psychiatry….The… alexithymia scores found in the CFS compared
with the RA patients were contrary to our original
hypothesis….There was no difference between CFS and RA patients
in hostility to mental illness….This study provides no evidence
to support the anti-psychiatry tone that is so striking in the
popular literature on CFS”
(Personality and Social Attitudes in Chronic Fatigue Syndrome. Barbara Wood and Simon Wessely; J Psychsom Res 1999:47:4:385-397). |
| “If one obtained identical results to the PACE trial, but this time with anti-viral drugs, the reaction would have been totally different. This is exactly what did happen when a very small trial of a drug that modulates the immune system (and which has some nasty side effects) was greeted with acclaim from the same sources that tried to discredit the PACE trial, which tested interventions with an impeccable safety record”: GET for people with ME does not have an impeccable safety record. Indeed, there is abundant evidence from numerous surveys by ME/CFS charities of almost 5,000 patients that in such patients CBT is ineffective and that GET is unacceptable and sometimes positively harmful. |
Those surveys include one sponsored jointly by the ME Association and Action for ME (“Report on a Survey of Members of Local ME Groups”. Dr Lesley Cooper, 2000). Cooper found that “Graded exercise was felt to be the treatment that made more people worse than any other” and that it had actually harmed patients (http://www.afme.org.uk/res/img/resources/Group%20Survey%20Lesley%20Cooper.pdf)
Another survey of 2,338 ME/CFS sufferers (“Severely Neglected: M.E. in the UK”) was carried out in 2001 by Action for ME; its preliminary report stated: “Graded exercise was reported to be the treatment that had made most people worse”; in the final report, this was changed to stating that graded exercise had made 50% of patients worse (http://www.afme.org.uk/res/img/resources/Severely%20Neglected.pdf).
The 25% ME Group for the Severely Affected carried out a further survey in 2004 which found that 93% of respondents found GET to be unhelpful, with 82% reporting that their condition was made worse (http://www.25megroup.org/Group%20Leaflets/Group%20reports/March%202004%20Severe%20ME%20Analysis%20Report.doc).
In 2005, a report (“Our Needs, Our Lives”) published by The Young ME Sufferers Trust found that 88% had been made worse by exercise (http://www.tymestrust.org/pdfs/ourneedsourlives.pdf).
In June 2007, through Section 16b funding from the Scottish Government, Action for ME produced a report “Scotland ME/CFS Scoping Exercise Report”, which found that 74.42% were made worse by GET.
In 2008, Action for ME published another survey of over 2,760 patients (“M.E. 2008: What progress?”) which found that
one third had been made worse by GET and that at their worst, 88% were bed/housebound, being unable to shower, bathe or wash themselves, and that 15% were unable to eat unaided. The Press Release of 12th May was unambiguous: “Survey finds recommended treatment makes one in three people worse” (http://www.afme.org.uk/news.asp?newsid=355).
In 2009, the Norfolk and Suffolk ME Patient Survey of 225 respondents stated: “Respondents
found the least helpful and most harmful interventions were Graded Exercise Therapy and Cognitive Behavioural Therapy” (http://www.norfolkandsuffolk.me.uk/surveylink.html ).
The International Association of CFS/ME recently published an article by Tom Kindlon (Bulletin of the IACFS/ME: 2011:19(2):59-111: Reporting Harms Associated with Graded Exercise Therapy and Cognitive Behavioural Therapy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) that details
the high rates of adverse reactions to exercise, as well as dissecting the PACE Trial in relation to the heterogeneity of subjects, the tracking of adverse events and the lack of objective outcome measures.>As Ed Lewisohn correctly points out in correspondence relating to the Frenchay Hospital’s clinic at Bristol:
|
“You refer to ‘Frenchay Hospital’s specialist chronic fatigue, or ME clinic’, but ME is an incurable neurological condition and cannot be synonymous with chronic fatigue. Chronic fatigue syndrome is treated by psychiatrists with graded exercise therapy, but if exercise makes (it) better, then that condition is not ME….But many patients with ME are also sent to chronic fatigue centres and receive the same treatment: they are then, shockingly, made more ill” (http://www.thisisbristol.co.uk/chronic-fatigue-syndrome/story-14243686-detail/story.html ). |
There is thus an abundance of empirical evidence that GET can result in high rates of adverse effects.
Why is it that the Wessely School, who claim to be so committed to evidence-based medicine (EBM), are permitted to continue to disregard the evidence that proves them to be wrong about the nature of ME and about the efficacy of GET in those suffering from it?
The answer may be because, like so many of the Wessely School myths, EBM does not actually exist.
In 2009 Bruce Charlton, Professor of Theoretical Medicine at the University of Birmingham, clarified the facts in relation to EBM:
EBM, however, has proved invaluable to the Wessely School in the perpetuation of their own myths about and management of ME/CFS, to the advantage of both the state and the insurance industry.
Despite the relentless determination of the Wessely School to claim ME/CFS as a functional somatoform disorder (in his latest article, Wessely reiterates his claim that: “the greater the number of symptoms, the more likely the patient was to develop a mood or anxiety disorder”), medical science is at last ensuring that the Wessely era is coming to an end.
Whilst XMRV is now thought to be a laboratory contaminant (and the triumphant glee of those who rejoiced at this is to be greatly deplored), the role of a retrovirus has not yet been resolved: indeed, Dr Ian Lipkin of Columbia University and chief virus-hunter for the NIH was reported on the Wall Street Journal blog on 27th December 2011 by Amy Dockser Marcus to have said that all the scientists and doctors involved in the NIH study, including the authors of the retracted PNAS and Science papers, “are committed to completing this study because none of us believes that the issue of retroviral infection in CFS/ME is resolved”.
Retrovirology apart, there is now undeniable evidence of multi-system damage in ME/CFS, including inflammation of the blood vessels, hypoperfusion of the brain, delayed recovery of muscles after exercise, dysfunction of the immune and neuroendocrine systems, and evidence of marked abnormalities in gene expression profiling.
Professor Nancy Klimas is to head a new Institute for Neuroimmune Medicine (specifically ME/CFS) at Nova Southeastern University: she will be providing cutting edge research and education of health care professionals, combined with care of patients; she will focus on systems biology, connecting neuro-imaging experts with scientists researching inflammation and genomics/proteomics, as well as collaborating with experts in neurotoxicology.
There is also the work of Dr Jose Montoya’s Chronic Illness Initiative at Stanford; the husband and wife team of Drs Light at the University of Utah; Dr Derek Enlander’s Chronic Fatigue Initiative with a very large budget for research at Mount Sinai, as well as the Public Health and Neuroimmunology Unit (PHANU) at Bond University in Australia (http://forums.phoenixrising.me/content.php?519), plus the committed work of Professors Mark VanNess and Christopher Snell at the University of the Pacific, all of which disprove the beliefs of the Wessely School that ME/CFS is a behavioural disorder.
Furthermore, the UK Medical Research Council has finally recognised the need for biomedical research into ME/CFS and is funding £1.6 million for research into aspects including autonomic dysfunction, aberrant mitochrondrial and cytokine production in skeletal muscles, and immune system dysfunction.
As clinical psychologist Dr Dorothy Rowe pointed out in 1993:
|
“ People who know absolutely that they are right are very dangerous”(The Observer, 14th November 1993), but who paid any attention? Father Cormac Rigby did: “The greatest enemies of truth are those who think they have a monopoly of truth” (The Lord be with you; Family Publications, Oxford, 2004). |
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Last Update December 2011
